Research Article
Evaluation of Intralymphatic Immunotherapy in Allergic Rhinitis Patients: A Systematic Review and Meta-analysis
Table 1
Study characteristics and participants.
| | First author, published year | Country | Trial ID | Centers | Enrolled period | Allergen | No. of participants | No. of females | Total dosage | Booster dose | Injection interval (weeks) | FU | | Active group | Placebo group | Active group | Placebo group |
| | Hellkvist, 2018 [29] | Sweden | 2009-016815-39 | 2 | 2012 to 2015 | Birch and grass pollen | 24/30 | 27/30 | 6 | 10 | 3000 SQU | 0 | 4 | 36-63w | | Hellkvist, 2022 [31] | Sweden | NCT02679105/NCT02975479 | 3 | 2015 and 2016 | Grass pollen | 29/29 | 29/31 | 9 | 10 | 7000/9000/14000 SQU | 0 | 4-7 | 8mo | | Hjalmarsson, 2022 [30] | Sweden | NCT04296474 | 2 | 2012 to 2014 | Birch and grass pollen | 20/26 | 14/28 | 6 | 5 | 3000 SQU | 0 | 4 | 5-7y | | Hylander, 2016 [32] | Sweden | 2009-016815-39 | 1 | September 2010 to September 2011 | Birch and/or grass pollen | 20/21 | 15/15 | 8 | 6 | 3000 SQU | 0 | 3-4 | 36w | | Konradsen, 2020 [13] | UK | NCT03394508 | 1 | January 1, 2013, and December 31, 2015 | Birch and/or grass pollen | 27/31 | 12/13 | 8 | 2 | 3000/4000 SQU | 1 | 4-5 | 92-104w | | Park, 2021 [15] | Korea | NCT02665754 | 1 | 2016 to December 2018 | D. farinae, D. pteronyssinus, dogs, and cats | 17/19 | 13/13 | 11 | 8 | NA | 0 | 4 | 48-50w | | Patterson, 2016 [33] | USA | NCT01982474 | 1 | December 2013 to February 2014 | Grass pollen | 7/7 | 8/8 | Na | Na | 400 PNU/mL | 0 | 4 | 8w | | Senti, 2012 [38] | Switzerland | NCT00718679 | 1 | August to September 2008 | Cat dander | 8/12 | 5/8 | 8 | 6 | 14 μg | 0 | 4 | 43w | | Skaarup, 2021 [34] | Denmark | 2012-005227-33 | 1 | 2013 | Grass pollen | 23/24 | 12/12 | 12 | 5 | 3000/4000 SQU | 1 | 4 | 144w | | Terada, 2020 [35] | Japan | NA | 2 | NA | Japanese cedar pollen | 12/12 | 6/6 | 8 | 4 | 60 JAU | 0 | 4 | 130w | | Thompson, 2020 [36] | USA | NA | 1 | Mountain cedar allergy season of 2018 to 2019 | Mountain cedar pollen | 11/11 | 10/10 | 7 | 5 | 3 : 2000 w/v | 0 | 4 | 15-19w | | Weinfeld, 2020 [39] | Sweden | NCT04210193 | 1 | Autumn of 2014 | Birch and/or grass pollen | 13/13 | Na | Na | Na | 3000/4000 SQU | 1 | 4 | 84w | | Witten, 2013 [37] | Denmark | NA | 1 | Na | Grass pollen | 25/30 | 13/15 | 6 | 5 | 3000/6000 SQU | 0 | 2 | 35w |
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ILIT: intralymphatic immunotherapy; FU: follow-up time; SQU: standardized quality units; PNU: protein nitrogen units; JAU: Japanese allergy units; NA: not available.
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