Review Article

Role of Matrix Metalloproteinase-2 in the Development of Atherosclerosis among Patients with Coronary Artery Disease

Table 1

PRISMA 2020 item checklist [31].

Section and topicItem #Checklist itemLocation where item is reported

Title1Identify the report as a systematic reviewTitle, line 2
Abstract2See the PRISMA 2020 for Abstracts checklistTable 2
Introduction
Rationale3Describe the rationale for the review in the context of existing knowledge.Introduction, paragraphs 1–6
Objectives4Provide an explicit statement of the objective(s) or question(s) the review addressesIntroduction, paragraph 6, line 10
Methods
 Eligibility criteria5Specify the inclusion and exclusion criteria for the review and how studies were grouped for the synthesesMethodology, see 2.2
 Information sources6Specify all databases, registers, websites, organizations, reference lists, and other sources searched or consulted to identify studies. Specify the date when each source was last searched or consultedMethodology, see 2.1
 Search strategy7Present the full search strategies for all databases, registers and websites, including any filters and limits usedMethodology, see 2.1
 Selection process8Specify the methods used to decide whether a study met the inclusion criteria of the review, including how many reviewers screened each record and each report retrieved, whether they worked independently, and if applicable, details of automation tools used in the processMethodology, see 2.3
 Data collection process9Specify the methods used to collect data from reports, including how many reviewers collected data from each report, whether they worked independently, any processes for obtaining or confirming data from study investigators, and if applicable, details or automation tools used in the processMethodology, see 2.3
 Data items10aList and define all outcomes for which data were sought. Specify whether all results that were compatible with each outcome domain in each study were sought (e.g., for all measures, time points, analyses), and if not, the methods used to decide which results to collectMethodology, see 2.3
10bList and define all other variables for which data were sought (e.g., participant and intervention characteristics, funding sources). Describe any assumptions made about any missing or unclear informationTable 5
 Study risk of bias assessment11Specify the methods used to assess risk of bias in the included studies, including details of the tool(s) used, how many reviewers assessed each study and whether they worked independently, and if applicable, details of automation tools used in the processMethodology, see 2.4
 Effect measures12Specify for each outcome the effect measure(s) (e.g., risk ratio, mean difference) used in the synthesis or presentation of resultsMethodology, see 2.3, line 6.
 Synthesis methods13aDescribe the processes used to decide which studies were eligible for each synthesis (e.g., tabulating the study intervention characteristics and comparing against the planned groups for each synthesis (item #5))Methodology, see 2.3, line 4–6.
13bDescribe any methods required to prepare the data for presentation or synthesis, such as handling of missing summary statistics, or data conversionsInvolving article exporting from database into mendeley web taught by Mrs. Norizam Salamat
13cDescribe any methods used to tabulate or visually display results of individual studies and syntheses.Not applicable
13dDescribe any methods used to synthesize results and provide a rationale for the choice(s). If meta-analysis was performed, describe the model(s), method(s) to identify the presence and extent of statistical heterogeneity, and software package(s) usedNo statistical analysis was done
13eDescribe any methods used to explore possible causes of heterogeneity among study results (e.g., subgroup analysis, metaregression).Not applicable
13fDescribe any sensitivity analyses conducted to assess robustness of the synthesized resultsNot applicable
 Reporting bias assessment14Describe any methods used to assess risk of bias due to missing results in a synthesis (arising from reporting biases).Not applicable
 Certainty assessment15Describe any methods used to assess certainty (or confidence) in the body of evidence for an outcomeNot applicable
Results
 Study selection16aDescribe the results of the search and selection process, from the number of records identified in the search to the number of studies included in the review, ideally using a flow diagram (see Figure 1)Results, paragraph 1 and see Figure 2
16bCite studies that might appear to meet the inclusion criteria, but which were excluded, and explain why they were excludedTable 3
 Study characteristics17Cite each included study and present its characteristics.Results, paragraph 2–5 and see Table 4
 Risk of bias in studies18Present assessments of risk of bias for each included studyResults, paragraph 2, line 3, and see Table 4, column 6
 Results of individual studies19For all outcomes, present, for each study: (a) summary statistics for each group (where appropriate) and (b) an effect estimate and its precision (e.g., confidence/credible interval), ideally using structured tables or plotsResults, see Table 4, column 5
 Results of syntheses20aFor each synthesis, in brief summarize the characteristics and risk of bias among contributing studiesResults, see Table 4, column 2 and 6
20bPresent results of all statistical syntheses conducted. If meta-analysis was done, present for each the summary estimate and its precision (e.g., confidence/credible interval) and measures of statistical heterogeneity. If comparing groups, describe the direction of the effectResults, see Table 4, column 5
20cPresent results of all investigations of possible causes of heterogeneity among study resultsNot applicable
20dPresent results of all sensitivity analyses conducted to assess the robustness of the synthesized resultsNot applicable
 Reporting biases21Present assessments of risk of bias due to missing results (arising from reporting biases) for each synthesis assessedNot applicable
 Certainty of evidence22Present assessments of certainty (or confidence) in the body of evidence for each outcome assessedNot applicable
 Discussion23aProvide a general interpretation of the results in the context of other evidenceDiscussion, paragraph 1–7
23bDiscuss any limitations of the evidence included in the reviewNot applicable
23cDiscuss any limitations of the review processes usedStudy limitation
23dDiscuss implications of the results for practice, policy, and future researchConclusion
Other information
 Registration and protocol24aProvide registration information for the review, including register name and registration number, or state that the review was not registeredProtocol registration
24bIndicate where the review protocol can be accessed, or state that a protocol was not preparedProtocol registration
24cDescribe and explain any amendments to information provided at registration or in the protocol.Not applicable
 Support25Describe sources of financial or nonfinancial support for the review, and the role of the funders or sponsors in the reviewAcknowledgement
 Competing interests26Declare any competing interests of review authorsConflict of interest
 Availability of data, code, and other materials27Report which of the following are publicly available and where they can be found: template data collection forms; data extracted from included studies; data used for all analyses; analytic code; any other materials used in the reviewData availability statement