Penfluroidol Attenuates the Imbalance of the Inflammatory Response by Repressing the Activation of the NLRP3 Inflammasome and Reduces Oxidative Stress via the Nrf2/HO-1 Signaling Pathway in LPS-Induced Macrophages

Figure 1

The effect of penfluridol on the viability of macrophages. (a and b) RAW264.7 and THP-1 cells were treated with penfluridol (0, 0.5, 1, 1.25, 1.5, 2, and 3 μm) for 12, 24, and 48 hr, and the effect of penfluridol on the viability of RAW264.7 and THP-1 macrophages was detected by Enhanced Cell Counting Kit-8 (CCK-8). (c) Chemical structure formula of penfluridol. (d) The effect of penfluridol on LPS-induced RAW264.7 cell activity. (e) The effect of penfluridol on LPS-induced THP-1 cell activity. The data are shown as the mean ± SD, and one-way ANOVA was used to compare the differences. and .

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