Sorbitol Destroyed Intestinal Microfold Cells (M Cells) Development through Inhibition of PDE4-Mediated RANKL Expression

<div>PDE4 inhibition rescued sorbitol-mediated M-cell development: (a) a schematic model of mice received mannitol or sorbitol or sorbitol combined with DIP (6 <i>μ</i>M) for 6 weeks to establish a chronic model; (b) IF analysis of mature M cells labeled with GP2 in the intestine from the indicated group. Bar: 75 <i>μ</i>m.</div>

Mediators of Inflammation

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Figure 5

Figure 5: Sorbitol Destroyed Intestinal Microfold Cells (M Cells) Development through Inhibition of PDE4-Mediated RANKL Expression 