Epigenetic Regulation of Mesenchymal Stem Cells: A Focus on Osteogenic and Adipogenic Differentiation

Table 1

Examples of clinical applications of mesenchymal stem cells.

Author	Year	Indication	Outcome
Bang et al. [60]	2005	Cerebral ischemia	Functional recovery after ischemic stroke improved in MSC-treated patients compared to control patients
Dill et al. [61]	2009	IHD	Intracoronary MSC administration improved LVF after STEMI
Horwitz et al. [62]	2002	Metabolic bone disease	5 of 6 OI patients showed accelerated bone growth velocity after IV infusion of allogeneic MSCs
Marcacci et al. [63]	2007	Critical size bone defect	Implantation of HA scaffolds seeded with MSCs into diaphysis defects resulted in fusion between implant and host bone
Wakitani et al. [64]	2007	Cartilage defect	Direct site transplantation of MSCs into articular cartilage defects resulted in clinical symptom improvement and defect repair

MSC: mesenchymal stem cell; IDH: ischemic heart disease; LVF: left ventricular function; STEMI: ST-segment elevated myocardial infarction; OI: osteogenesis imperfecta; IV: intravenous; HA: hydroxyapatite.