Fibroblast Growth Factor-2 Enhances Expansion of Human Bone Marrow-Derived Mesenchymal Stromal Cells without Diminishing Their Immunosuppressive Potential
Figure 5
Effect of time-in-culture on the immunosuppressive activity of hMSCs. Immunosuppressive activity in conditioned medium from IL-1β-stimulated hMSCs at different passages cultured under control conditions. Values are normalized to the inhibition observed conditioned medium from first passage hMSCs. The mean and standard deviation for all 5 hMSC preparations are displayed in (a); the 3 hMSC preparations that exhibited sustained activity are displayed in (b); the mean and standard deviation for the 2 hMSC preparations that exhibited decreased activity after 4 passages are displayed in (c). Asterisks indicate significant differences in one-tail paired t-test; .
