Optimization Manufacture of Virus- and Tumor-Specific T Cells
Figure 1
Increased frequency of antigen-specific CTLs after in vitro stimulation. (a) illustrates the low frequency of antigen-specific CTLs present in peripheral blood and the subsequent enrichment after antigen stimulation. (b) shows the enrichment of QAKWRLQTL- (HLA-B8-restricted EBV epitope-) specific T cells in a seropositive donor as evaluated by tetramer analysis. (c) illustrates the inverse correlation between the frequency of antigen-specific and alloreactive T cells in peripheral blood (left) and in vitro expanded CTLs (right).
