In Vivo Healing of Meniscal Lacerations Using Bone Marrow-Derived Mesenchymal Stem Cells and Fibrin Glue

Table 2

Group 0 is fibrin only treatment; Group 1 is fibrin with BMSCs treatment. See Table 1 for grading score rubric.

Category/Score	Group	0	1	2	3	𝑃 value
Gross observations
Adherent vessels	Group 0	4 (33.3%)	3 (25%)	5(41.7%)		0.0094
	Group 1	0 (0%)	10 (83.3%)	2 (16.7%)
Tissue adhesion	Group 0	5 (41.7%)	7 (58.3%)			1.00
	Group 1	5 (41.7%)	7 (58.3%)
Bond	Group 0		2 (16.7%)	10 (83.3%)		0.640
	Group 1		4 (33.3%)	8(66.7%)
H&E section observations
Cellular in-growth	Group 0	3(25.0%)	6 (50.0%)	3(25.0%)		1.000
	Group 1	3(25.0%)	5 (41.7%)	4 (33.3%)
Predominant cell type	Group 0		8 (66.7%)	1(8.3%)	3(25.0%)	0.822
	Group 1		6(50.0%)	1(8.3%)	5(41.7%)
Fiber organization	Group 0	3(25.0%)	7(58.3%)	2(16.7%)		1.000
	Group 1	2(16.7%)	7 (58.3%)	3(25.0%)
Fibrinous tissue between sections	Group 0	7(58.3%)	5(41.7%)			0.214
	Group 1	3(25.0%)	9(75.0%)
Total bond distance	Group 0	0	3(25.0%)	4(33.3%)	5(41.7%)	0.569
	Group 1	0	1(8.35)	7(58.3%)	4(33.3%)
SOFG section observations
SOFG % positive staining	Group 0	5(41.7%)	3(25.0%)	4(33.3%)	0	0.428
	Group 1	5(41.7%)	5(41.7%)	1(8.3%)	1(8.3%)
Thickness of repair tissue	Group 0		5(41.7%)	6(50.0%)	1(8.3%)	0.680
	Group 1		8(66.7%)	3(25.0%)	1(8.3%)
Cell repopulation	Group 0	5(41.7%)	6(50.0%)	1(8.3%)		0.520
	Group 1	7(58.3%)	3(25.0%)	2(16.7%)