Use of Autologous Mesenchymal Stem Cells Derived from Bone Marrow for the Treatment of Naturally Injured Spinal Cord in Dogs
Table 2
Summary of clinical and imaging findings in dogs submitted to MSC.
(a)
Clinical findings
Dog 1
Dog 2
Dog 3
Dog 4
Before MSC
100 d
12 mo
Before MSC
100 d
12 mo
Before MSC
100 d
12 mo
Before MSC
100 d
12 mo
Tail movement
(−)
(−)
Partial gain
(−)
Total gain
Total gain
(−)
(−)
Partial gain
(−)
(−)
(−)
Panicculi reflex
(−)
Partial gain
Partial gain
(−)
(−)
Partial gain
(−)
Partial gain
Partial gain
(−)
Partial gain
Partial gain
Urinary bladder continence
(−)
Partial gain
Partial gain
(−)
Partial gain
Partial gain
(−)
Partial gain
(−)
(−)
(−)
(−)
Propioc. Reflex
(−)
Partial gain
Partial gain
(−)
Partial gain
Partial gain
(−)
(−)
(−)
(−)
(−)
(−)
Weight bearing
(−)
(−)
(−)
(−)
1 min
1 min
(−)
(−)
(−)
(−)
(−)
(−)
(b)
Before MSC
12 mo
Before MSC
12 mo
Before MSC
12 mo
Before MSC
12 mo
MFS
0
1
0
1
0
0
0
0
Before MSC
18 mo
Before MSC
18 mo
Before MSC
18 mo
Before MSC
18 mo
Rx
0
0
0
0
0
0
0
0
Before MSC: before administration of MSC; 100 d: 100 days after MSC transplantation; 12 mo: 12 months after MSC transplantation; MFS: modified Frankel score; propioc proprioception; Rx: radiogram evaluation (0: neither proliferative/erosive observations nor fracture/luxation of the spine; 1: presence of signs of proliferative/erosive alterations or fracture/luxation of the spine).
