The Secretome of Bone Marrow and Wharton Jelly Derived Mesenchymal Stem Cells Induces Differentiation and Neurite Outgrowth in SH-SY5Y Cells
Figure 4
Quantitative analysis of SH-SY5Y neurite outgrowth seven days after incubation with BMSCs and HUCPVCs CM. Quantification of neurite lengths showed that for all CM conditions, with exception of SH-SY5Y cells cultured with BMSCs CM 96 h, the CM of BMSCs and HUCPVCs induced a neurite outgrowth and length very similar to the RA-differentiated cells group (). The decrease in the mean neurite length observed in the BMSCs CM 96 h group () suggests that the neuronal differentiation inducement of SH-SY5Y cells may be associated with the temporal profile of MSCs CM collection (values are shown as mean ± SEM, , ).
