Phenotypic and Proteomic Characteristics of Human Dental Pulp Derived Mesenchymal Stem Cells from a Natal, an Exfoliated Deciduous, and an Impacted Third Molar Tooth
Table 3
Classification of the proteins that were identified by MALDI-TOF/TOF analysis. The classifications were made based on PANTHER analysis and Swiss-Prot annotations.
Protein name
Function
Biological process involved
Apoptosis related
Galectin
Apoptosis, cell proliferation, and differentiation
Apoptosis
Cathepsin B
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins.
Regulation of apoptotic process and proteolysis
Cathepsin D
Acid protease active in intracellular protein breakdown
Regulation of apoptotic process and proteolysis
Histidine triad nucleotide-binding protein 1
Hydrolyzes purine nucleotide phosphoramidates
Apoptosis
Signal transduction
SA100A6
May function as calcium sensor and modulator, contributing to cellular calcium signaling
Signal transduction
Protein S100-A11
Signal transduction
Annexin A1
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis
Cell surface receptor signaling pathway
Protein biosynthesis and degradation
Ubiquitin
Behaves as a molecular tag for degradation of proteins
Processing of ubiquitin precursors and of ubiquitinated proteins
Ubl conjugation pathway
39S ribosomal protein L12, mitochondrial
Ribonucleoprotein
Mitochondrial protein biosynthesis
Proteasome subunit alpha type 1
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH
Immunity
Proteasome subunit beta type 7
Cleavage of peptide bonds with very broad specificity
Protein degradation
Transcription related
Heterogeneous nuclear ribonucleoprotein A/B
Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA
Transcription, transcription regulation
Heterogeneous nuclear ribonucleoprotein D0
Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3′-UTR of many protooncogenes and cytokine mRNAs
Transcription, transcription regulation
Heterogeneous nuclear ribonucleoprotein H
This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation
Mediates pre-mRNA alternative splicing regulation
Heterogeneous nuclear ribonucleoprotein D-like
Acts as a transcriptional regulator. Promotes transcription repression.
Transcription, transcription regulation
Paraspeckle component 1
Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line
Transcription, transcription regulation
Nucleotide metabolism
UMP-CMP kinase
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP
Nucleotide metabolism
Nucleoside diphosphate kinase A
Major role in the synthesis of nucleoside triphosphates other than ATP
Nucleotide metabolism
Redox metabolism related
Thioredoxin domain-containing protein 12
Possesses significant protein thiol-disulfide oxidase activity
Oxidoreductase
Peroxiredoxin-2
Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system
Hydrogen peroxide catabolic process removal of superoxide radicals
Superoxide dismutase Cu-Zn
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Antioxidant, oxidoreductase
Thioredoxin-dependent peroxide reductase
Peroxidase activity, peroxiredoxin activity
Involved in redox regulation of the cell
Glutathione S-transferase P
Conjugation of reduced glutathione to a wide number of exogenous and endogenous substrates
Glutathione derivative biosynthetic process
Persulfide dioxygenase ETHE1, mitochondrial
Plays ab essential role in hydrogen sulfide catabolism in the mitochondrial matrix
Hydrogen sulfide metabolic process
Protein folding/stress
Tubulin-specific chaperone A
Involves the early step of the tubulin folding pathway.
Chaperone binding
UPF0556 protein C19orf10
Involved in unfolded protein response, cellular protein metabolic process
Protein DJ-1
Protects cells against oxidative stress and cell death.
Oxidative stress
Heat shock protein beta-1
Involved in stress resistance and actin organization.
Stress response
Heat shock cognate 71 kDa protein
Acts as a repressor of transcriptional activation
Stress response
60 kDa heat shock protein, mitochondrial
Implicated in mitochondrial protein import and macromolecular assembly
de novo' protein folding, stress response
78 kDa glucose-regulated protein
Plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum
ER overload response
Peptidyl-prolyl cis-trans isomerase A
It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
PPIases accelerate the folding of proteins
Tripeptidyl-peptidase 1
Lysosomal serine protease with tripeptidyl-peptidase I activity
Involved in unfolded protein response
Energy metabolism
ATP synthase subunit D
ATP synthesis
Energy metabolism
Phosphoglycerate mutase 1
Interconversion of 3- and 2-phosphoglycerate
Glycolysis, gluconeogenesis
Alpha-enolase
Role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance, and allergic responses.
Vimentins are class-III intermediate filaments found in various nonepithelial cells, especially mesenchymal c
Intermediate filament organization
Macrophage-capping protein
Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function.
