Concise Review: Mesenchymal Stem Cells Ameliorate Tissue Injury via Secretion of Tumor Necrosis Factor-α Stimulated Protein/Gene 6

Figure 1

MSCs interaction with immune cells or inflammatory cells during inflammation results in production of many cytokines that moderate the inflammatory environment. MSCs have been confirmed to affect immune regulation and tissue repair. In the inflammatory environment of injured tissue, MSC interactions with T cells, macrophages, and dendritic cells result in inhibition of inflammation. Many factors have been identified as contributing to this response, especially TSG-6.