Neural Differentiation of Human Pluripotent Stem Cells for Nontherapeutic Applications: Toxicology, Pharmacology, and In Vitro Disease Modeling

Table 3

In vitro modeling of neurodegenerative and neurodevelopmental disorders with hPSCs-derived neuronal lineages.

Disease model	Key references
Alzheimer’s disease	Israel et al. [84]
Huntington’s disease	An et al. [85]; The HD iPSC Consortium [86]
Amyotrophic lateral sclerosis	Mitne-Neto et al. [87]
Autism spectrum disorder	Kim et al. [88]
Schizophrenia	Chiang et al. [89]; Brennand et al. [90]
Rett syndrome	Ananiev et al. [91]; Cheung et al. [92]; Li et al. [93]; Williams et al. [94]
Fragile X syndrome	Sheridan et al. [95]; Bar-Nur et al. [96]; Liu et al. [97]
Timothy syndrome	Paşca et al. [98]; Krey et al. [99]