Effect of Increasing Doses of γ-Radiation on Bone Marrow Stromal Cells Grown on Smooth and Rough Titanium Surfaces

Figure 10

Analysis of mRNAs expression of Runx2, OCN, PPARγ, and P53 under different dose of radiation on PT or SLA surfaces at the 7th and the 14th days. Runx2 was higher at the 7th day than the 14th day under the situation. But OCN was higher at the 14th day. Radiation decreased them in a dose-dependent manner, and they are higher on SLA surfaces than on PT surfaces with the same dose of radiation. PPARγ was higher at the 14th day than the 7th day under the same situation. 2 Gy radiation increased expression of PPARγ on both surfaces. But it significantly decreased with 4 Gy and 8 Gy radiation on both surfaces. And it was higher on PT surfaces than on SLA surfaces with the same dose of radiation. Radiation increased expression of P53 tightly associated with dosage. It was significantly increased under 4 Gy and 8 Gy radiation. P53 was higher at the 7th day than at the 14th day on both surfaces under the same dose of radiation. Compared to PT surfaces, it was lower on SLA surfaces. And the difference was smaller on the 14th day than on the 7th day. .