Hedgehog and Resident Vascular Stem Cell Fate

Figure 1

Posttranslational processing of Hh proteins. (a) The unprocessed Hh protein contains a 20 KDa N-terminal fragment (Hh-N) and a 25 KDa C-terminal self-splicing fragment (Hh-C). (b) Autoproteolysis occurs and a cholesterol molecule becomes covalently bound to the C-terminal of Hh-N. Hh-C is later degraded in the ER. (c) Addition of Palmitoleic Acid results in the fully processed form of the protein (Hh-Np) and mediates its transport to the cell membrane.