Stem Cells International

Review Article

Hedgehog and Resident Vascular Stem Cell Fate

Table 1

Expression profiles and locations of resident stem and progenitor cells within the blood vessel wall.


Cell type	Expression profile	Location within the blood vessel wall

AdvSca1⁺ progenitor cells	Sca1⁺, c-kit⁺, Lin⁻, α-SMA⁻, SM22⁻, Calponin⁻, and SM-MHC⁻	Tunica adventitia [67]
AdvSca1⁺ progenitor cells	Sca1⁺, c-kit⁻, CD140b⁺, CD45⁻, CD68⁻, Shh⁺, Ptch1⁺, Ptch2⁺, Smo⁺, Gli1⁺, Gli2⁺, Gli3⁺, Hhip⁺, Cdo⁺, and Boc⁺	Tunica adventitia [6]

MSCs	CD29⁺, CD44⁺, CD14⁻, and CD45⁻	Tunica media [68]
	CD146⁺, CD34⁻, CD45⁻, CD56⁻, vWF⁻, Pax7⁻, CD144⁻, NG2⁺, α-SMA⁺, PDGF-Rβ⁺, Alkaline Phosphatase⁺, Myogenin⁻, N-Cadherin⁻, Myf5⁻, CD10⁺, CD13⁺, CD44⁺, CD73⁺, CD90⁺, CD105⁺, CD108⁺, CD109⁺, CD140b⁺,CD164⁺, CD166⁺, CD318⁺, CD340⁺, CD349⁺, SSEA-4⁺, HLA-CL⁺, CD106⁻, CD133⁻, CD324⁻, CD326⁻, CD344⁻, HLA-DR⁻	Tunica media [69]
	CD13⁺, CD29⁺, CD44⁺, CD49a⁺, CD49b⁺, CD59⁺, CD73⁺, CD90⁺, CD105⁺, CD31⁻, CD34⁺, CD133⁻, c-kit⁻, CD146⁻, CD45⁻, Desmin⁺, Vimentin⁺, Oct3⁻, Oct4⁻, and NANOG⁻ (additional markers were present in some of the population: NG2⁺ (62% ± 6%), PDGF-Rβ⁺ (48% ± 2%), Sox2⁺ (75% ± 17%), α-SMA⁺ (12% ± 10%), β3-tubulin⁺ (58% ± 15%), and Nestin⁺ (20% ± 9%))	Tunica adventitia [70]
	CD13⁺, CD29⁺, CD44⁺, CD54⁺, CD90⁺, HLA Class1⁺, CD14⁻, CD31⁻, CD33⁻, CD34⁻, CD45⁻, CD106⁻, CD133⁻, KDAR⁻, Cadherin-5⁻, and HLA-DR⁻	Tunica media and tunica adventitia [71]

MVSCs	Sox10⁺, Sox1⁺, Snail⁺, Vimentin⁺, Nestin⁺, Sox17⁺, NFM⁺, Peripherin⁺, Brn3a⁺, Phox2b⁺, S100β⁺, CD29⁺, CD44⁺, ki67⁺, α-SMA⁺ (weak), SM-MHC⁻, CNN1⁻, CD146⁻, Sca1⁻, CD31⁻, CD144⁻, CD34⁻, CD133⁻, c-Kit⁻, Flk-1⁻, and Sox2⁻	Tunica media and tunica adventitia [19]