What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?

Figure 1

Characterization of UCX (a) and BM-MSCs (b). (A) Both MSCs showed a fibroblast-like morphology (175x amplified). Representative photo of cultured cells is at passage 5, 3 days after seeding 10.000 cells/cm². (B) Flow cytometry analysis of MSC surface-markers expression of cells expanded for 5 passages. (C) Both MSCs were capable of trilineage differentiation. After 21 days of exposure to adipogenic, chondrogenic, and osteogenic differentiation media, results showed (i) Oil Red O staining for adipocytes, (ii) alcian blue staining for chondrocytes, and (iii) alkaline phosphatase staining for osteoblasts. Controls (CT) are shown in the upper left corner of each differentiation photo.