What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?

Figure 2

UCX are less immunogenic than BM-MSCs. PBMCs from two different donors were incubated with a non-MSC cell line (Molt4), BM-MSC, and UCX from 3 independent donors. Lymphocyte proliferation was measured as []thymidine uptake (ccpm). UCX, and to a lesser extent BM-MSC, failed to induce lymphocyte activation in an allogeneic MLR. Values are represented as mean s.e.m. and statistically significant differences are indicated by asterisks (one-way ANOVA with a Tukey posttest; , , and ).