What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?

Figure 4

Effect of UCX in an acute inflammation model. Wistar rats (7 to 8 weeks old) were treated either with PBS vehicle (sham control), BM-MSCs (1.7 × 10⁶ cells), UCX (1.7 × 10⁶ cells), or UCX previously activated with 10 ng/mL of TNFα and IFNγ (1.7 × 10⁶ cells), 1 hour prior to challenge with -carrageenan in the right paw. Anti-inflammatory effect in vivo was assessed by measuring the paw volume at maximum peak time – 6 h, relative to the preinjection volume. Data is presented as mean s.e.m. and statistically significant differences are indicated by asterisks (nonparametric test Mann Whitney; , , and ).