Exosomes Secreted from CXCR4 Overexpressing Mesenchymal Stem Cells Promote Cardioprotection via Akt Signaling Pathway following Myocardial Infarction

Figure 6

Effects of exosome pretreated MSC patch on in vivo angiogenesis in infarcted myocardium. (a) The vessel formation in the infarcted border area was identified by vWF (green color, yellow arrows). Cardiomyocytes were identified by cardiac troponin T (cTnT) and all nuclei were stained with DAPI. Scale bar = 100 µm. Original magnification ×400. (b) Quantitative data for vessel density in treatment groups. versus MI group; versus MI + group. (c) Masson’s trichrome staining and quantitative data for fibrotic size in various treatments. (d) The percentage of infarct size in hearts of various groups. versus MI; versus MI + group. Sham: sham operated rats had a loose suture placed around the LAD coronary artery; MI (myocardial infarction alone created by LAD ligation); MI + PBS (MI + PBS alone treatment); MI + MSC (MI + MSC transplantation); MI + (MI + pretreated MSC transplantation); MI + (MI + pretreated MSC); MI + (MI + pretreated MSC). versus MI; versus MI + MSC. All values expressed as mean ± SEM, for each group.

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