A New Paradigm in Cardiac Regeneration: The Mesenchymal Stem Cell Secretome

Figure 1

The broad repertoire of MSCs secretome has considerable potential for the treatment of CVD. In the context of myocardial protection, potential therapeutic mechanisms established by MSCs secretome include tissue preservation, angiogenesis, beneficial cardiac remodeling, anti-inflammatory responses, and finally promotion of endogenous regeneration of the heart. CPCs: cardiac progenitor cells; CSCs: cardiac stem cells; ECs: endothelial cells; ECM: extracellular matrix.