Adipose-Derived Mesenchymal Stem Cell Exosomes Suppress Hepatocellular Carcinoma Growth in a Rat Model: Apparent Diffusion Coefficient, Natural Killer T-Cell Responses, and Histopathological Features

Figure 5

T1-weighted ((a), (e), and (i)), enhanced T1-weighted ((b), (f), and (j)), DW image (b value = 800 sec/mm²) ((c), (g), and (k)), and ADC map ((d), (h), and (l)) of HCC at the level of greatest tumor diameter on baseline (a, b, c, d), posttreatment day 10 ((e), (f), (g), and (h)), and posttreatment day 20 ((i), (j), (k), and (l)). MR imaging of a control rat shows heterogeneously enhanced tumor with marked enlargement (whole-tumor volume ratios: D₁₀/baseline = 1.38, D₂₀/baseline = 1.85) whilst the ADC value (whole-tumor ADC ratios: D₁₀/baseline = 0.92, D₂₀/baseline = 1.04) remains low. Gross specimen (M) of the resected liver shows a large tumor in the left lobe with good correlation to MR imaging on posttreatment day 20.

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