Adipose-Derived Mesenchymal Stem Cell Exosomes Suppress Hepatocellular Carcinoma Growth in a Rat Model: Apparent Diffusion Coefficient, Natural Killer T-Cell Responses, and Histopathological Features

Figure 6

T1-weighted ((a), (e), and (i)), enhanced T1-weighted ((b), (f), and (j)), DW image (b value = 800 sec/mm²) ((c), (g), and (k)), and ADC map ((d), (h), and (l)) of HCC at the level of greatest tumor diameter on baseline ((a), (b), (c), and (d)), posttreatment day 10 ((e), (f), (g), and (h)), and posttreatment day 20 ((i), (j), (k), and (l)). MR imaging of an exosome-treated rat shows partial but nonsignificant tumor reduction and significantly increased ADC ratio on posttreatment day 10 (D₁₀/baseline whole-tumor volume ratio = 0.72 and ADC ratio = 1.29). On posttreatment day 20, the exosome-treated rat harbored significantly smaller tumor and higher ADC ratio (D₂₀/baseline whole-tumor volume ratio = 0.29 and ADC ratio = 1.63). Gross specimen (M) of the resected liver shows a small lobulated tumor in the left lobe with good correlation to MR imaging on posttreatment day 20.

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