Adipose-Derived Mesenchymal Stem Cell Exosomes Suppress Hepatocellular Carcinoma Growth in a Rat Model: Apparent Diffusion Coefficient, Natural Killer T-Cell Responses, and Histopathological Features

Table 2

Within-group and intergroup comparisons of tumor volumes, volume ratios, and ADC and ADC ratios of HCC between the control group and exosome-treated group.

	Control; mean ± SD	Exosome-treated; mean ± SD
Tumor volume (mm^3)
Baseline	3816 ± 580	3905 ± 595	.798
D10	5320 ± 412^*	3437 ± 632	.002
D2	6719 ± 625^*†	1625 ± 587^*†	<.001
Tumor volume ratio
D10/baseline	1.38 ± 0.18	0.83 ± 0.08	<.001
D20/baseline	1.74 ± 0.21	0.42 ± 0.13	<.001
(D20/baseline versus D10/baseline)	.012^‡	.012^‡
ADC (×10^−3 mm^2/sec)
Baseline	0.71 ± 0.08	0.70 ± 0.07	.959
D10	0.72 ± 0.09	0.83 ± 0.11^*	.028
D20	0.73 ± 0.08	1.01 ± 0.06^*†	<.001
ADC ratio
D10/baseline	1.01 ± 0.18	1.19 ± 0.12	.038
D20/baseline	1.04 ± 0.19	1.43 ± 0.17	<.001
(D20/baseline versus D10/baseline)	.674^‡	.017^‡

D_B: baseline, D₁₀: posttreatment day 10, D₂₀: posttreatment day 20.
P < .05 for comparison with baseline values (Tukey-Kramer multiple comparison test).
P < .05 for comparison with day D₁₀ values (Tukey-Kramer multiple comparison test).
Wilcoxon signed rank test, Mann-Whitney test.