Adipose-Derived Mesenchymal Stem Cell Exosomes Suppress Hepatocellular Carcinoma Growth in a Rat Model: Apparent Diffusion Coefficient, Natural Killer T-Cell Responses, and Histopathological Features

Table 3

Comparisons of percentages of circulating NKT-cells at different time points, HCC differentiation, and intratumoral CD8α+ NKT-cells between the control group and exosome-treated group.

	Control; mean ± SD; ()	Exosome-treated; mean ± SD; ()
Circulating NKT-cells (%)
Before HCC induction	0.45 ± 0.35	0.55 ± 0.36	.574^*
Pretreatment	1.28 ± 0.37	1.25 ± 0.33	.878^*
Posttreatment day 5	1.43 ± 0.47	2.63 ± 0.59	.001^*
Posttreatment day 10	0.69 ± 0.29	2.44 ± 0.57	<.001^*
HCC tumor differentiation
E-S grade (I-II : III-IV)	1 : 7	8 : 0	<.001^†
Intratumoral NKT-cells
Number of CD8α+ cells/HPF	5.1 ± 2.7	18.7 ± 3.5	<.001^*

NKT-cells: natural killer T-cells, E-S: Edmondson-Steiner, HPF: high power field.
Mann-Whitney test.
Fisher’s exact test.