Multipotent Mesenchymal Stromal Cells: Possible Culprits in Solid Tumors?

Table 3

Immunomodulation by MSCs and TAFs.

Tumor entity	Effects observed	Effects mediated by	Literature
Cervical cancer	Downregulation of HLA-I in cervical cancer by T-MSCs cell lines and reduced cytolysis by CTL-cells	IL-10	[26]
Melanoma	Impairment of NK cell answer against melanoma cells by reduced upregulation of NKp44, NKp33, and DNAMI after exposure to T-MSCs	(i) Reduction of NKp44 and expression (mediated by PGE2); (ii) Reduction of DNAMI expression (depending on cell to cell contact)	[64, 65]
Pancreatic cancer	Depletion of arginine renders tumor infiltrating T cells dysfunctional	Expression of ARG2 and arginine depletion	[66]
NSCLC	CD3/CD28 depending activation of T cells	IL-6	[67]
Follicular lymphoma	MSCs from follicular lymphoma patients display increased recruitment of TAM and a distinct gene expression profile	Overexpression of CCL2	[68]