SDF-1/CXCR4 Axis Promotes MSCs to Repair Liver Injury Partially through Trans-Differentiation and Fusion with Hepatocytes

Figure 1

MSCs recruited to injured tissue and transdifferentiated into hepatocyte-like cells. (a) The liver specimens were collected on days 2, 3, 4, 7, 14, 21, and 28 after injury. FISH was used to detect Y-chromosome-positive cells, and IF was used to detect ALB-positive cells. The nuclei were stained blue (DAPI). The images were then merged. Bar: 75 μm. Arrow was directed to the double positive cells. All the experiments were repeated three times, at least 3 samples were included in each group. (b) Quantitative data of the ALB and Y-chromosome-positive cells in IHC of different days after injuring (^**; ^***).

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