Overcoming Therapeutic Resistance of Bone Sarcomas: Overview of the Molecular Mechanisms and Therapeutic Targets for Bone Sarcoma Stem Cells

Figure 1

Overview of bone sarcoma stem cells. Although there is no consensus on the definitive marker, a wide range of CSC markers (black) and the molecular mechanisms underlying CSC phenotypes (blue) have been documented for each sarcoma. Several anti-CSC compounds (red) have been preclinically tried to inhibit CSC phenotypes. a, osteosarcoma; b, Ewing sarcoma; c, chondrosarcoma.