Bone Formation by Sheep Stem Cells in an Ectopic Mouse Model: Comparison of Adipose and Bone Marrow Derived Cells and Identification of Donor-Derived Bone by Antibody Staining

Figure 1

Study design. CEAC from adipose tissue (A-CEAC) and bone marrow (BM-CEAC) was isolated from 5 female sheep, expanded in vitro, and seeded onto HA prior to subcutaneous implantation in immunodeficient mice. After 8 weeks, implants were harvested and bone volume versus total tissue volume was assessed by histomorphometry. Each mouse received four implants as previously described [19].