PS1/γ-Secretase-Mediated Cadherin Cleavage Induces β-Catenin Nuclear Translocation and Osteogenic Differentiation of Human Bone Marrow Stromal Cells

<div>Expression of E-cadherin, N-cadherin, and β-catenin in osteoinduced and Dapt-treated BMSCs. Confocal microscopy images showing the expression of E-cadherin ((a) red), N-cadherin ((b) red), β-catenin ((c) green), and Pan-cadherin ((d) green) by BMSCs cultured for 48 h with expansion medium (CT, control undifferentiated), osteogenic medium (OM), or osteogenic medium containing 20 μM of the PS1/γ-secretase inhibitor Dapt (Dapt + OM). Dapt was added 24 h before the addition of OM. Nuclei were stained with DAPI (blue). Scale bars = 25 μm.</div>

Stem Cells International

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Figure 3: PS1/γ-Secretase-Mediated Cadherin Cleavage Induces β-Catenin Nuclear Translocation and Osteogenic Differentiation of Human Bone Marrow Stromal Cells

Figure 3 | PS1/γ-Secretase-Mediated Cadherin Cleavage Induces β-Catenin Nuclear Translocation and Osteogenic Differentiation of Human Bone Marrow Stromal Cells 