Tissue Inhibitor of Matrix Metalloproteinases-1 Knockdown Suppresses the Proliferation of Human Adipose-Derived Stem Cells

<div>Effects of TIMP-1 knockdown on p53 protein and cell cycle biomarkers. The levels of p53, p21, cyclin E, CDK2, and P-CDK2 proteins were analyzed by western blotting after TIMP-1 knockdown. (a) The representative western blot images. (b) The expression levels of p53, p21, cyclin E, CDK2, and P-CDK2 were quantified by the densitometry of each band and were normalized by internal loading control, <i>β</i>-actin. 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Parent: uninfected ADSCs; mock: control lentivirus infected ADSCs; shTIMP-1: shRNA-TIMP-1 lentivirus infected ADSCs.</div>

Stem Cells International

fig6

Figure 6

Figure 6: Tissue Inhibitor of Matrix Metalloproteinases-1 Knockdown Suppresses the Proliferation of Human Adipose-Derived Stem Cells 