Towards Therapeutic Delivery of Extracellular Vesicles: Strategies for In Vivo Tracking and Biodistribution Analysis

Table 2

Extracellular vesicles targeting studies.

Target cells	Ligand	Receptor	Main reference
APCs	Lactadherin-fusion	Antigen targeting	[68, 69]
Neurons	RVG-Lamp2b fusion	Acetylcholine receptor	[70–72]
B cells	EBV glycoprotein 350	CD19	[73]
Breast cancer	PDGFR-GE11 peptide fusion	EGFR	[60]
	RGD-	αvβ3 integrins	[74]
Cancer cells	Iron oxide nanoparticles	Magnetic targeting	[75]
Carcinoma cells	Nanobodies anti-EGFR fused to GPI anchors	EGFR	[76]
	Nanobodies anti-EGFR conjugated with PEG		[77]
Different targets	Viral envelope proteins	Dependent on the type of the virus	[78]
	Exosome fusion with liposomes	Dependent on the type of the hybrid exosome	[79, 80]
	Click chemistry modification	Dependent on the type of the functionalization	[81, 82]