Fate and Effect of Intravenously Infused Mesenchymal Stem Cells in a Mouse Model of Hepatic Ischemia Reperfusion Injury and Resection

Figure 2

(Anti-)inflammatory and cytoprotective response. (a) mRNA levels of inflammatory marker IL-6 showed no differences six hours after reperfusion. Forty-eight hours after reperfusion mice treated with MSC 2 hours before IRI and PH showed significant lower expression levels of IL-6 compared to PBS treated mice. (b) Inflammatory markers TNF-α showed no significant difference after reperfusion. (c) Cytoprotective gene HO-1 showed no significant differences between mice treated with MSC or PBS at both time points. (d) Anti-inflammatory gene IL-10 showed no significant differences between MSC or PBS treated mice. The data are expressed as means ± SEM (() versus their PBS controls).

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