Downregulation of the Yes-Associated Protein Is Associated with Extracellular Matrix Disorders in Ascending Aortic Aneurysms

Figure 1

(a) Intraoperative images and CTA showing the enlarged ascending aorta in an ascending aortic aneurysm. (b) Elastin staining showed obvious derangement of tissue structure of the ascending aorta in ascending aortic aneurysm. (c, d) Confocal fluorescence microscopy showed that the number of TUNEL and α-SMA double-staining cells was clearly increased in the ascending aortic walls of ascending aortic aneurysms (). (e) Immunohistochemistry showed that the cleaved caspase-3 staining was strong and Bcl-2 staining was weak in the ascending aortic walls of ascending aortic aneurysms relative to normal.

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