Heart-Derived Stem Cells in Miniature Swine with Coronary Microembolization: Novel Ischemic Cardiomyopathy Model to Assess the Efficacy of Cell-Based Therapy

Figure 2

Regional and global function after microembolization. Regional and global function were severely depressed and remained constant until 3 months. The temporal changes of wall thickening (%) and Δwall thickness (mm) in the LAD and normal remote regions are summarized in (a) and (b). As early as 10 minutes after microembolization, regional wall thickening in LAD and remote regions was significantly reduced and remained constant until 3 months. Although LV end-diastolic and end-systolic dimensions slowly increased, global function remained depressed until 3 months ((c), (d), and (e)). LVDd: left ventricular distance diastole. LVDs: left ventricular distance systolic.

(a)

(b)

(c)

(d)

(e)