Heart-Derived Stem Cells in Miniature Swine with Coronary Microembolization: Novel Ischemic Cardiomyopathy Model to Assess the Efficacy of Cell-Based Therapy

Figure 3

The effects of CDCs on infarction area and connective tissue area. (a) Postmortem analysis by TTC demonstrated that microembolization produced extensive myocardial infarction in anterior-septal region (%). Global infusion of CDCs significantly reduced infarction area (%). Data indicate CDC infusion reduced infarction area and increased viable myocardium. (b) Masson staining demonstrates myocardial fibrosis (blue area) in myocardium (red area). Representative images demonstrate that CDCs significantly reduced fibrotic areas compared to untreated controls. (c) Global infusion of CDCs significantly reduced LAD fibrosis (% to %, ) as well as in the RCA remote region (% to %, ).

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