Heart-Derived Stem Cells in Miniature Swine with Coronary Microembolization: Novel Ischemic Cardiomyopathy Model to Assess the Efficacy of Cell-Based Therapy

Figure 6

The effects of CDCs on TUNEL positive myocytes. The upper panel represents TUNEL positive nuclei localized in cardiac myocytes. Two TUNEL positive nuclei (green, arrow) localized to myocytes by cTnI staining (red). One TUNEL positive nonmyocyte nucleus located in the interstitial space (). The lower graph summarizes the number of TUNEL positive myocytes detected in the heart, expressed as nuclei per million myocytes. After CDCs, there was no significant change in the number of TUNEL positive myocytes in ischemic LAD and remote regions.