Acute Hypoxic Stress Affects Migration Machinery of Tissue O₂-Adapted Adipose Stromal Cells

Table 1

Differential gene expression in tissue O₂-adapted ASCs after short-term hypoxic stress.

Gene name	Description	Fold regulation	value
PI3K-AKT signalling pathway
APC	Adenomatous polyposis coli	−2,37	0,001822
CHUK	Conserved helix-loop-helix ubiquitous kinase	−1,77	0,002
EIF4E	Eukaryotic translation initiation factor 4E	−1,75	0,025246
FASLG	Fas ligand (TNF superfamily, member 6)	−7,69	0,027667
GJA1	Gap junction protein, alpha 1, 43 kDa	−2,05	0,000032
IGF1	Insulin-like growth factor 1 (somatomedin C)	−1,86	0,000335
MTOR	Mechanistic target of rapamycin (serine/threonine kinase)	−1,58	0,00017
PDK1	Pyruvate dehydrogenase kinase, isozyme 1	1,62	0,00023
PIK3CA	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	−1,76	0,000144
PTEN	Phosphatase and tensin homolog	−1,55	0,000564
RASA1	RAS p21 protein activator 1	−1,72	0,000345
RBL2	Retinoblastoma-like 2 (p130)	−1,53	0,000685
RHEB	Ras homolog enriched in brain	−1,56	0,001571
RPS6KB1	Ribosomal protein S6 kinase, 70 kDa	−1,91	0,000001
TLR4	Toll-like receptor 4	−1,75	0,000149
Cytoskeleton regulators
ACTR3	ARP3 actin-related protein 3 homolog	−1,68	0,007654
CCNA1	Cyclin A1	−3,56	0,001399
CCNB2	Cyclin B2	−1,58	0,03013
DSTN	Destrin (actin depolymerising factor)	−1,62	0,000256
MACF1	Microtubule-actin cross-linking factor 1	−1,56	0,005851
MID1	Midline 1	−2,11	0,000067
NCK1	NCK adaptor protein 1	−1,70	0,000862
MYPT1	Protein phosphatase 1, regulatory (inhibitor) subunit 12A	−1,77	0,006053
ROCK1	Rho-associated, coiled-coil containing protein kinase 1	−1,61	0,000288
TIAM1	T-cell lymphoma invasion and metastasis 1	−1,57	0,00189
WASF1	WAS protein family, member 1	−1,56	0,000922
MAP kinase signalling pathway
CDKN2B	Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	−2,05	0,000059
CDKN2D	Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	1,68	0,000229
E2F1	E2F transcription factor 1	−1,90	0,002717
FOS	c-fos	1,99	0,002614
MAP2K1	MEK1	1,89	0,000016
MAP2K6	MKK6	−2,37	0,002281
MAPK7	ERK4	1,70	0,000529
MAPK13	p38delta	1,51	0,000418
SFN	Stratifin	1,57	0,000872
TP53	Tumour protein p53	−2,03	0,000005