Umbilical Cord Tissue-Derived Mesenchymal Stem Cells Induce T Lymphocyte Apoptosis and Cell Cycle Arrest by Expression of Indoleamine 2, 3-Dioxygenase

Figure 1

T lymphocyte inhibition potentials of 4 MSCs. (a) T lymphocytes proliferation was inhibited by MSCs in coculture. The data are expressed as the means ± SD from 5 independent experiments. The inhibitory effect of UC-MSC coculture groups on T lymphocytes proliferation was more prominent than that of the AT-, WJ-, and BM-MSC group. when compared to the BM-MSC. (b) T lymphocyte apoptosis induced by MSCs in coculture. The apoptotic ratio of UC-MSC coculture groups on T lymphocytes was much highly prominent compared to that of the AT-, WJ-, and BM-MSC group. (c) G0/G1 phase arrest of T lymphocytes induced by MSCs in coculture. The arrest effect of the UC-MSC coculture groups on T lymphocytes was more prominent than that of the AT-, WJ-, and BM-MSC group.

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