Umbilical Cord Tissue-Derived Mesenchymal Stem Cells Induce T Lymphocyte Apoptosis and Cell Cycle Arrest by Expression of Indoleamine 2, 3-Dioxygenase

Figure 4

1-MT reverses the effect of hUC-MSCs on T lymphocyte apoptosis. Cultured T lymphocytes were stimulated for 120 h with PHA in the presence or absence of hUC-MSCs. 1-MT was included in some cultures. At harvest, the cells were stained with antibodies to annexin V and PI and analyzed by flow cytometry. (a) The FACS plots were representative of one of three experiments. (b) The results of three independent experiments were averaged. Bars represent the SD. .

(a)

(b)