Umbilical Cord Tissue-Derived Mesenchymal Stem Cells Induce T Lymphocyte Apoptosis and Cell Cycle Arrest by Expression of Indoleamine 2, 3-Dioxygenase

Figure 5

UC–MSCs suppressed Bcl-2 expression and induced caspase 3 expression during coculture with T lymphocytes. Cultured T lymphocytes were stimulated for 120 hours with PHA in the presence or absence of hUC-MSCs and treated with 1-MT. At harvest, the mRNA was isolated and subjected to RT-PCR for Bcl-2 (a) and caspase 3 (b). The data are presented as the means ± SD from 3 independent experiments. Bars represent the SD. .

(a)

(b)