Derivation of Pluripotent Cells from Mouse SSCs Seems to Be Age Dependent

Figure 4

(a) Heat map and (b–d) correlation analyses reveal expression levels of core pluripotency genes Oct4, Nanog, and Sox2 decrease in SSCs with age of the animal. A decline in Oct4, Nanog, and Sox2 expression is clearly observable after 7 weeks of age and becomes even more evident after 12 weeks of age. Arrows in (b–d) mark the localization of Oct4, Nanog, and Sox2 in the correlations.

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