A Controlled Release Codelivery System of MSCs Encapsulated in Dextran/Gelatin Hydrogel with TGF-<i>β</i>3-Loaded Nanoparticles for Nucleus Pulposus Regeneration

<div>Schematic diagram of establishing the codelivery system of MSCs encapsulated in the dextran/gelatin hydrogel with the TGF-<i>β</i>3-loaded nanoparticles. After the TGF-<i>β</i>3-loaded PLGANPs were prepared using the W/O/W method, the MSCs and the TGF-<i>β</i>3-loaded PLGANPs were incubated with the Oxi-Dex and amino-Gel solution. The codelivery system was formed by the Schiff-based reaction between the Oxi-Dex and amino-Gel. The TGF-<i>β</i>3 could be released gradually with degradation of the PLGANPs for long-term discogenesis differentiation.</div>

Stem Cells International

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Figure 1

Figure 1: A Controlled Release Codelivery System of MSCs Encapsulated in Dextran/Gelatin Hydrogel with TGF-<i>β</i>3-Loaded Nanoparticles for Nucleus Pulposus Regeneration 

Figure 1 | A Controlled Release Codelivery System of MSCs Encapsulated in Dextran/Gelatin Hydrogel with TGF-β3-Loaded Nanoparticles for Nucleus Pulposus Regeneration 