FGF2 Attenuates Neural Cell Death via Suppressing Autophagy after Rat Mild Traumatic Brain Injury

Figure 4

Effects of FGF2 on the expression of autophagy-related proteins in the ipsilateral cortex 48 h post-TBI in different groups. (a) Representative Western blots showing levels of Beclin-1, p62, and LC3 in the ipsilateral cortex 48 h post-TBI. Lane 1, sham group; lane 2, TBI + vehicle group; lane 3 TBI + FGF2 group. (b, c) The relative band densities of Beclin-1 and p62. The densities of the protein bands were analyzed and normalized to β-actin. The data are expressed as a percentage of the sham group. The bars represent the mean ± SD. . versus sham and ^# versus TBI + vehicle. (d) The band density ratio of LC3 II to LC3 I. The bars represent the mean ± SD. . versus sham and ^# versus TBI + vehicle.

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