Mesenchymal Stromal Cells Are More Immunosuppressive In Vitro If They Are Derived from Endometriotic Lesions than from Eutopic Endometrium

Figure 3

Protein and gene expression of the immunosuppressive enzymes IDO1, COX2, and HO-1 and the proinflammatory chemokine CXCL12 in ESC_endo and ESC_cyst by flow cytometry and qPCR, respectively. The percentage of cells expressing IDO1 is higher for ESC_cyst (). ESC_cyst express higher levels of IDO1 by MFI (). ESC_cyst have higher gene expression of IDO1 (). The percentage of cells expressing COX2 is higher for ESC_cyst (). ESC_cyst express higher levels of COX2 by MFI (). ESC_cyst have higher gene expression of COX2 (). The percentage of cells expressing HO-1 is higher for ESC_cyst (). ESC_cyst express higher levels of HO-1 by MFI (). ESC_cyst have higher gene expression of HO-1 (). The percentage of cells expressing CXCL12 is higher for ESC_cyst (). ESC_cyst express higher levels of CXCL12 by MFI (). ESC_cyst have lower gene expression of CXCL12 (). Four independent experiments ( biological replicates) were carried out in duplicates. Mean ± SD.