When Long Noncoding RNAs Meet Genome Editing in Pluripotent Stem Cells

Table 2

Classification of lncRNA functional mechanisms and the location of lncRNAs.

Mechanism of function	Examples	Ref.
Nucleus
Regulating chromatin-modifying complexes	ANRIL	[47]
	HOTAIR	[48]
Recruiting transcription factors	HERVH	[17]
	PWR1	[49]
	TUNA	[50]
Chromatin remodeling	HOTTIP	[51]
	SRG1	[52]
	fbp1 ncRNA	[53]
Influencing pre-mRNA splicing	MALAT1	[18]
	EGFR-AS1	[54]
Cytoplasm
Regulating mRNA stability	Linc-RoR	[55]
	Gadd7	[56]
	MEG3	[57]
Regulating mRNA translation	lincRNA-p21	[19]
	Antisense Uchl1	[58]
Competing for microRNA binding	HPAT5	[59]
	HULC	[60]
Translated in biologically active small peptides	LINC00961	[61]