Galectin-3 Knockdown Impairs Survival, Migration, and Immunomodulatory Actions of Mesenchymal Stromal Cells in a Mouse Model of Chagas Disease Cardiomyopathy

Figure 8

Ultrastructural analysis of T. cruzi infected MSC. Viable parasites were found in the cytosol of MSC-WT (a) and inside parasitophorous vacuoles of MSC-Gal3KD (b), 24 h after infection. (c and e) Viable parasites are seen in the cytosol of MSC-WT 72 h after infection. (d and f) Absence of viable parasites and presence of large vacuoles containing degraded material in the MSC-Gal3KD 72 h after infection. White arrows = viable parasites’; K = kynetoplast; PN = parasite nucleus; PV = parasitophorous vacuole.

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