The Immunomodulatory Effects of Mesenchymal Stem Cell Polarization within the Tumor Microenvironment Niche

Figure 4

Interaction between macrophages and the MSCs in promoting tumor growth. M1 macrophages could activate the MSCs to adopt a regulatory phenotype, and the MSCs with an altered secretory profile promoted tumor growth by iNOS and MCP1 and induced macrophages toward M2-like macrophages.