Optogenetic Inhibition of Striatal Neuronal Activity Improves the Survival of Transplanted Neural Stem Cells and Neurological Outcomes after Ischemic Stroke in Mice

<div>The validation of laser stimulation efficiency and the optimization of laser power based on electrophysiological recording in mouse striatum at 21 days after virus injection. (a) Excitatory stimulation with 473 nm laser pulse in the striatal area expressing ChR2. (b) Inhibitory stimulation with 530 nm constant laser in striatal area expression ArchT. (c) Uninterrupted stimulation with 1 mW 530 nm laser for 15 minutes did not affect the local spontaneous action potentials after the stimulation is finished.</div>

Stem Cells International

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Figure 2: Optogenetic Inhibition of Striatal Neuronal Activity Improves the Survival of Transplanted Neural Stem Cells and Neurological Outcomes after Ischemic Stroke in Mice 

Figure 2 | Optogenetic Inhibition of Striatal Neuronal Activity Improves the Survival of Transplanted Neural Stem Cells and Neurological Outcomes after Ischemic Stroke in Mice 