Research Article
Mitochondrial Maturation in Human Pluripotent Stem Cell Derived Cardiomyocytes
Figure 3
EM images of undifferentiated RuES2 hPSC (a), early stage RuES2 PSC-CM (b), late stage RuES2 PSC-CM (c), and late stage IMR90 iPSC-CM (d) at lower (upper panel) and higher magnification (lower panel). Quantitative analysis of relative abundance of mitochondria (e, calculated by mitochondria area/cell area) and mitochondrial size (f). Data represented as mean ± SEM, for early stage and for late stage. Data represented as mean ± SEM. For each condition 16 fields were examined.
| (a) Undifferentiated hPSC |
| (b) Early hPSC-CM |
| (c) Late hPSC-CM (RUES2) |
| (d) Late hPSC-CM (IMR90) |
| (e) Relative abundance (%) |
| (f) Mt size (μm2) |