Mitochondrial Maturation in Human Pluripotent Stem Cell Derived Cardiomyocytes

Figure 3

EM images of undifferentiated RuES2 hPSC (a), early stage RuES2 PSC-CM (b), late stage RuES2 PSC-CM (c), and late stage IMR90 iPSC-CM (d) at lower (upper panel) and higher magnification (lower panel). Quantitative analysis of relative abundance of mitochondria (e, calculated by mitochondria area/cell area) and mitochondrial size (f). Data represented as mean ± SEM, for early stage and for late stage. Data represented as mean ± SEM. For each condition 16 fields were examined.

(a) Undifferentiated hPSC

(b) Early hPSC-CM

(c) Late hPSC-CM (RUES2)

(d) Late hPSC-CM (IMR90)

(e) Relative abundance (%)

(f) Mt size (μm²)